Patient Support

PROCESS

Pre-assessment And
Administration Process

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FAQ

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Patient Support FAQ

  • Who Is Eligible For CAR T-Cell Immunotherapy?

    Patients must meet the following criteria to be eligible for CAR T-Cell Immunotherapy:
    • Patient is well enough to receive CAR T-Cell Immunotherapy.
    • Tumour has expressed the appropriate marker, e.g. CD19.
    • An Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
    • Absence of disease complications or chemo-toxicity; such as, infection, active GVHD, hyperleucocytosis, severe extra medullary disease.
    • Last dose of chemotherapy and/or steroid is at least 2 weeks prior; when in doubt, a T-Cell activation test will be performed.
    • Patient’s tumour burden is as low as possible. In patients with uncontrolled or accelerating tumour burden, induction chemotherapy should be performed first (apheresis should be done prior to commencing the chemotherapy).

  • What Are The Possible Side Effects Of CAR T-Cell Immunotherapy?

    • Cytopenia – Cytopenia occurs when one or more of the blood cell types are lower than it should be. Blood consists of red blood cells which carry oxygen and nutrients around the body, and white blood cells which fight infection.
    • B-Cell Aplasia – B-Cell aplasia occurs when anti-CD19 CAR T-Cells kill normal B lymphocytes that express CD19. These patients are typically at high risk of developing infections, because of their hypogammaglobulinemia. However, this can be treated with intravenous immunoglobulin (IVIG) replacement therapy.
    • Cytokine Release Syndrome (CRS) – Potentially life-threatening condition that results from the pathologic over-activation of T-Cells. It is an acute systemic inflammatory syndrome characterised by fever and multiple organ dysfunction.
    • Neurotoxicity – Damage to the brain or peripheral nervous system caused by exposure to natural or man-made toxic substances. These toxins can alter the activity of the nervous system in ways that can disrupt or kill nerves.

  • What If The Requirements For CAR T-Cell Immunotherapy Are Not Met?

    • T-Cell Cryopreservation Option
    If any of the above requirements are not met for the patient to be eligible to undergo the CAR T-Cell immunotherapy for the time being, there is an option for the patient to freeze their T- Cells for future use once treatment can proceed.

  • How Long Is The CAR T-Cell Immunotherapy Treatment Process?

    1. Pre-assessment – Up to 4 weeks.
    2. Pre-treatment phase (apheris, CAR T-Cell manufacturing, conditioning chemotherapy) – Up to 6 weeks.
    3. Treatment (CAR T-Cell infusion, monitoring) – Up to 1 week.
    4. Post-treatment Monitoring (follow up) – Up to 24 weeks.
    Disclaimer: The actual immunotherapy treatment process is dependent on individual patients and the type of cancer.

  • Other Safety Information

    The information stated above is a brief summary for CAR T-Cell Immunotherapy. For more information, kindly contact us to set an appointment with our healthcare partners.

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    For a more in-depth understanding on
    CAR T-Cell Immunotherapy, we’ve
    prepared a brochure that provides you
    with the information you need.

    For a more in-depth understanding on CAR T-Cell Immunotherapy, we’ve prepared a brochure that provides you with the information you need.

    Have Any Questions About CAR T-Cell
    Immunotherapy That Isn’t Listed On Our FAQ Page?
    Reach Out To Us And We’ll Get In Touch.

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      Copyright © 2021 Malaysian Genomics Resource Centre Berhad (652790-V). All Rights Reserved.

      Copyright © 2021 Malaysian Genomics Resource Centre Berhad (652790-V). All Rights Reserved.