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CAR T-Cell FAQ

  • Who Qualifies for CAR T-Cell Immunotherapy?

    Patients must meet the following criteria to be eligible for CAR T-Cell Immunotherapy:
    • Patient is well enough to receive CAR T-Cell Immunotherapy.
    • Tumour has expressed the appropriate marker, e.g. CD19.
    • An Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
    • Absence of disease complications or chemo-toxicity; such as, infection, active GVHD, hyperleucocytosis, severe extra medullary disease.
    • Last dose of chemotherapy and/or steroid is at least 2 weeks prior; when in doubt, a T-Cell activation test will be performed.
    • Patient’s tumour burden is as low as possible. In patients with uncontrolled or accelerating tumour burden, induction chemotherapy should be performed first (apheresis should be done prior to commencing the chemotherapy).

  • What Are the Possible Side Effects of CAR T-Cell Immunotherapy?

    • Cytopenia – Cytopenia occurs when one or more of the blood cell types are lower than it should be. Blood consists of red blood cells which carry oxygen and nutrients around the body, and white blood cells which fight infection.
    • B-Cell Aplasia – B-Cell aplasia occurs when anti-CD19 CAR T-Cells kill normal B lymphocytes that express CD19. These patients are typically at high risk of developing infections, because of their hypogammaglobulinemia. However, this can be treated with intravenous immunoglobulin (IVIG) replacement therapy.
    • Cytokine Release Syndrome (CRS) – Potentially life-threatening condition that results from the pathologic over-activation of T-Cells. It is an acute systemic inflammatory syndrome characterised by fever and multiple organ dysfunction.
    • Neurotoxicity – Damage to the brain or peripheral nervous system caused by exposure to natural or man-made toxic substances. These toxins can alter the activity of the nervous system in ways that can disrupt or kill nerves.

  • What Is the Treatment Period Like for CAR T-Cell Immunotherapy?

    • The pre-evaluation phase takes up to 4 weeks. Once completed, blood collection will take 1 day. The process of manufacturing the CAR T-Cells will then take up to 4 weeks, after which you will have to undergo pre-conditioning chemo, which can last up to 4 days (2 to 14 days before CAR T-Cell infusion. After you’re done with that, the infusion of the CAR T-Cell will take 1 day, and your follow up will be between 3 to 6 months later.
    However, do note that each CAR T-Cell product is custom made and patient specific. Pre-evaluation and post monitoring will differ according to the patient’s condition.

  • What Does Compassionate Drug Mean and Why Is CAR T-Cell Under This Category?

    Compassionate drug use means making a new drug, which is still in clinical trials, available to treat a seriously ill patient when no other treatments are available. This is different from the use of drugs as part of a clinical trial, which is called Investigational Use. Such drugs are only available to patients who are taking part in a clinical trial. Being able to use one of these drugs when the patient is not part of a clinical trial is commonly referred to as compassionate drug use.

    Doctors and patients wishing to use CAR T-Cell Immunotherapies for solid tumours can do so under a special process called Compassionate Drug Use.

  • Is CAR T-Cell Immunotherapy Better Than Chemotherapy?

    Chemotherapy, surgery and radiotherapy are USFDA-approved treatments that have long been used as primary and secondary treatments for cancer.

    However, when cancer recurs in the future, or when these primary and secondary treatments are unable to reduce or kill cancer, then doctors and patients may opt for other types of treatments including immunotherapy and also drugs that are still undergoing clinical trials nearing FDA approval. The clinical outcomes of CAR T-Cell Immunotherapy have been impressive and have shown remarkable results in relapsed/refractory cancer patients.

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    For a more in-depth understanding on
    CAR T-Cell Immunotherapy, we’ve
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    with the information you need.

    For a more in-depth understanding on CAR T-Cell Immunotherapy, we’ve prepared a brochure that provides you with the information you need.

    Have any questions about CAR T-Cell
    Immunotherapy that isn’t listed on our FAQ page?
    Reach out to us and we’ll get in touch.

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      Copyright © 2021 Malaysian Genomics Resource Centre Berhad (652790-V). All Rights Reserved.

      Copyright © 2021 Malaysian Genomics Resource Centre Berhad (652790-V). All Rights Reserved.