Who Is Eligible For CAR T-Cell Immunotherapy?

Patients must meet the following criteria to be eligible for CAR T-Cell Immunotherapy:

• Patient is well enough to receive CAR T-Cell Immunotherapy.
• Tumour has expressed the appropriate marker, e.g. CD19.
• An Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
• Absence of disease complications or chemo-toxicity; such as, infection, active GVHD, hyperleucocytosis, severe extra medullary disease.
• Last dose of chemotherapy and/or steroid is at least 2 weeks prior; when in doubt, a T-Cell activation test will be performed.
• Patient’s tumour burden is as low as possible. In patients with uncontrolled or accelerating tumour burden, induction chemotherapy should be performed first (apheresis should be done prior to commencing the chemotherapy).